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Science. Support. Hope for people affected by TMAU.

TMAU International is dedicated to improving the lives of people affected by trimethylaminuria through support, education, research, and advocacy.

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Support

Compassionate community support and connection for individuals and families affected by TMAU.

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Research & Advocacy

Advancing research and raising awareness to improve care and drive meaningful change.

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What is TMAU?

Trimethylaminuria (TMAU) is a rare genetic metabolic condition that affects the body’s ability to break down trimethylamine (a compound produced in the gut from certain foods). This can result in a strong body odor often described as fishy, which can impact quality of life.

Symptoms

Strong body odor, especially after eating certain foods like fish, eggs, or legumes.

Diagnosis

Diagnosed through clinical evaluation and specialized testing.

Management

Management includes diet, lifestyle strategies, and ongoing support.

Our Impact, Our Future

We’re just getting started, and every step forward brings hope to a community that’s been waiting far too long to be seen.

Building Community

Growing a global network of patients, families, and allies.

Funding Research

Investing in the science needed to change lives.

Understanding the Science

Science drives our mission. Research brings us closer to better treatments and a brighter future.

Metabolism

TMAU occurs when the body cannot properly break down trimethylamine due to low or nonfunctional FMO3 enzyme activity.

Trimethylamine (TMA)

TMA is produced in the gut from certain foods and normally metabolized in the liver. In TMAU, it builds up and causes odor.

Genetics

Variants in the FMO3 gene impair the enzyme needed to convert TMA into a non-odorous compound.

Research

Ongoing studies aim to improve understanding, diagnosis, and potential treatments for TMAU.